New Device Powers Wearable Sensors Through Human Motion
10-16-20
Wei Gao, Assistant Professor of Medical Engineering, has been developing sensors as well as novel approaches to power them. Previously, he created a sensor that could monitor health indicators in human sweat that is powered by sweat itself. Now, Gao has developed a new way to power wireless wearable sensors: He harvests kinetic energy that is produced by a person as they move around. "Instead of using fancy materials, we use commercially available flexible circuit boards," he says. "This material is cheap and very durable and mechanically robust over long periods of time." [Caltech story]
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Wei Gao
Professor Gao Unveils Sensor that Rapidly Detects COVID-19 Infection Status, Severity, and Immunity
10-02-20
One feature of the COVID-19 virus that makes it so difficult to contain is that it can be easily spread to others by a person who has yet to show any signs of infection. Professor Wei Gao has developed a new type of multiplexed test (a test that combines multiple kinds of data) with a low-cost sensor that may enable the at-home diagnosis of a COVID infection through rapid analysis of small volumes of saliva or blood, without the involvement of a medical professional, in less than 10 minutes. "This is the only telemedicine platform I've seen that can give information about the infection in three types of data with a single sensor," Gao says. "In as little as a few minutes, we can simultaneously check these levels, so we get a full picture about the infection, including early infection, immunity, and severity." [Caltech story]
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Seeing Through Opaque Media
05-12-20
Changhuei Yang, Thomas G. Myers Professor of Electrical Engineering, Bioengineering, and Medical Engineering, has developed a technique that combines fluorescence and ultrasound to peer through opaque media, such as biological tissue. "We hope that one day this method can be deployed to extend the operating depth of fluorescence microscopy and help image fluorescent labeled cells deep inside living animals," says Yang. [Caltech story]
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New Ultrafast Camera Takes 70 Trillion Pictures Per Second
05-04-20
A new camera developed by Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, is capable of taking as many as 70 trillion frames per second. The camera technology, which Wang calls compressed ultrafast spectral photography (CUSP), combines a laser that emits extremely short pulses of laser light that last only one quadrillionth of a second (one femtosecond) with optics and a specialized type of camera. The technology could open up new avenues of research in fields that include fundamental physics, next-generation semiconductor miniaturization, and the life sciences. "We envision applications in a rich variety of extremely fast phenomena, such as ultrashort light propagation, wave propagation, nuclear fusion, photon transport in clouds and biological tissues, and fluorescent decay of biomolecules, among other things," Wang says. [Caltech story]
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Lihong Wang
Electronic Skin Fully Powered by Sweat Can Monitor Health
04-23-20
One of the ways we experience the world around us is through our skin. From sensing temperature and pressure to pleasure or pain, the many nerve endings in our skin tell us a great deal. Our skin can also tell the outside world a great deal about us as well. Wei Gao, Assistant Professor of Medical Engineering has developed an electronic skin, or e-skin, that is applied directly on top of your real skin. "We want this system to be a platform," he says. "In addition to being a wearable biosensor, this can be a human–machine interface. The vital signs and molecular information collected using this platform could be used to design and optimize next-generation prosthetics." [Caltech story]
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Wei Gao
Sweat Sensor Detects Stress Levels; May Find Use in Space Exploration
02-27-20
Wei Gao, Assistant Professor of Medical Engineering, has produced a wireless sweat sensor that can accurately detect levels of cortisol, a natural compound that is commonly thought of as the body's stress hormone. This could allow for more widespread and easier monitoring of stress, anxiety, post-traumatic stress disorder, and depression. "We aim to develop a wearable system that can collect multimodal data, including both vital sign and molecular biomarker information, to obtain the accurate classification for deep space stress and anxiety," Gao says. [Caltech story]
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Professor Wang Advances Photoacoustic Imaging Technology
02-25-20
Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed variants of photoacoustic imaging that can show organs moving in real time, develop three-dimensional (3-D) images of internal body parts, and even differentiate cancerous cells from healthy cells. Photoacoustic imaging, a technique for examining living materials through the use of laser light and ultrasonic sound waves, has many potential applications in medicine because of its ability to show everything from organs to blood vessels to tumors. Wang has now further advanced photoacoustic imaging technology with what he calls Photoacoustic Topography Through an Ergodic Relay (PATER), which aims to simplify the equipment required for imaging of this type. [Caltech story]
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Lihong Wang
Professor Wang Develops World's Fastest Camera
01-21-20
Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed the world's fastest camera, a device capable of taking 10 trillion pictures per second. It's so fast that it can even capture light traveling in slow motion. "What we've done is to adapt standard phase-contrast microscopy so that it provides very fast imaging, which allows us to image ultrafast phenomena in transparent materials," says Wang. [Caltech story]
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Lihong Wang
