Changhuei Yang Named to National Academy of Inventors
12-10-20
Changhuei Yang, Thomas G. Myers Professor of Electrical Engineering, Bioengineering, and Medical Engineering, has been named fellow of the National Academy of Inventors (NAI). Election as a fellow is the highest professional distinction accorded to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development and the welfare of society. The Yang lab develops technologies aimed at transforming the conventional microscope so that it can be used for high-throughput, automated applications. He also works on the use of "time-reversal" techniques to undo the effect of tissue light scattering. [Caltech story] [List of 2020 Fellows]
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Seeing Through Opaque Media
05-12-20
Changhuei Yang, Thomas G. Myers Professor of Electrical Engineering, Bioengineering, and Medical Engineering, has developed a technique that combines fluorescence and ultrasound to peer through opaque media, such as biological tissue. "We hope that one day this method can be deployed to extend the operating depth of fluorescence microscopy and help image fluorescent labeled cells deep inside living animals," says Yang. [Caltech story]
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Noise-Canceling Optics
10-10-16
Changhuei Yang, Professor of Electrical Engineering, Bioengineering, and Medical Engineering, and colleagues have created the visual analogue of noise-canceling headphones—a camera system that can obtain images of objects obscured by murky media, such as fog or clouds, by canceling out the glare. Their device selectively cancels the scattered light, leaving only the light that is reflected or bounced off the objects and has slipped back through the murk unmolested. [Caltech story]
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Popping Microbubbles Help Focus Light Inside the Body
12-03-15
Changhuei Yang, Professor of Electrical Engineering, Bioengineering, and Medical Engineering, and his postdoctoral colleague Dr. Haowen Ruan have developed a novel technique called time-reversed ultrasound microbubble encoded (TRUME) that uses gas-filled microbubbles to focus light inside tissue. "Ultrasound and X-ray techniques can only detect cancer after it forms a mass," Yang says. "But with optical focusing, you could catch cancerous cells while they are undergoing biochemical changes but before they undergo morphological changes." [Caltech story]
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Pushing Microscopy Beyond Standard Limits
07-29-13
Changhuei Yang, Professor of Electrical Engineering and Bioengineering, and colleagues have shown how to make cost-effective, ultra-high-performance microscopes. The final images produced by their new system contain 100 times more information than those produced by conventional microscope platforms. And building upon a conventional microscope, their new system costs only about $200 to implement. This new method could have wide applications not only in digital pathology but also in everything from hematology to wafer inspection to forensic photography. [Caltech Release]
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Changhuei Yang Develops "Microscope on a Chip"
07-28-08
Changhuei Yang, Assistant Professor of Electrical Engineering and Bioengineering, and colleagues have turned science fiction into reality with their development of a super-compact high-resolution microscope, small enough to fit on a finger tip. This "microscopic microscope" operates without lenses but has the magnifyingpower of a top-quality optical microscope, can be used in the field to analyze blood samples for malaria or check water supplies for giardia and other pathogens, and can be mass-produced for around $10.
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