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Recording Brain Activity with Laser Light

06-07-21

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has demonstrated for the first time a new technology for imaging the human brain using laser light and ultrasonic sound waves. The technology, known as photoacoustic computerized tomography, or PACT, has been developed as a method for imaging tissues and organs. Now, Wang has made further improvements to the technology that make it so precise and sensitive that it can detect even minute changes in the amount of blood traveling through very tiny blood vessels as well as the oxygenation level of that blood. [Caltech story]

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Studying Chaos with One of the World's Fastest Cameras

01-14-21

There are things in life that can be predicted reasonably well. The tides rise and fall. A billiard ball bounces around a table according to orderly geometry. And then there are things that defy easy prediction: The hurricane that changes direction without warning. The splashing of water in a fountain. These phenomena and others like them can be described as chaotic systems. Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed a new tool that might help to better understand chaotic systems. [Caltech story]

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Lihong Wang Named to National Academy of Inventors

12-10-20

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has been named fellow of the National Academy of Inventors (NAI). Election as a fellow is the highest professional distinction accorded to academic inventors who have demonstrated a prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development and the welfare of society. The Wang lab has developed photoacoustic imaging that allows researchers to see into biological tissues noninvasively, and to peer deeper into the body by nearly two orders of magnitude compared to conventional optical microscopy. [Caltech story] [List of 2020 Fellows]

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Lihong Wang Receives NIH BRAIN Grant

12-07-20

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has received funding for neuroscience projects from the National Institutes of Health's Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Wang and his team aim to develop a technology called 3D photoacoustic computed tomography (PACT) that will rapidly image large-scale neural activity in human brains with high sensitivity. "Photoacoustic imaging of adult human brains is one of the most challenging frontiers in our field," says Wang. "It requires innovation to overcome the signal attenuation and wavefront distortion due to the skull. I'm glad that the NIH has the vision to fund this worthy research direction." [Caltech story]

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Ultrafast Camera Films 3-D Movies at 100 Billion Frames Per Second

10-19-20

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed technology that can reach blistering speeds of 70 trillion frames per second, fast enough to see light travel. Just like the camera in your cell phone, though, it can only produce flat images. Now, Wang's lab has gone a step further to create a camera that not only records video at incredibly fast speeds but does so in three dimensions. [Caltech story]

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Lei Li Wins Charles Wilts Prize

06-02-20

Lei Li advised by Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, is a winner of this year's Charles Wilts Prize, for his doctoral thesis "Multi-contrast Photoacoustic Computed Tomography." The Charles Wilts Prize is awarded every year to a graduate student in Electrical Engineering for outstanding independent research.

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New Ultrafast Camera Takes 70 Trillion Pictures Per Second

05-04-20

A new camera developed by Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, is capable of taking as many as 70 trillion frames per second. The camera technology, which Wang calls compressed ultrafast spectral photography (CUSP), combines a laser that emits extremely short pulses of laser light that last only one quadrillionth of a second (one femtosecond) with optics and a specialized type of camera. The technology could open up new avenues of research in fields that include fundamental physics, next-generation semiconductor miniaturization, and the life sciences. "We envision applications in a rich variety of extremely fast phenomena, such as ultrashort light propagation, wave propagation, nuclear fusion, photon transport in clouds and biological tissues, and fluorescent decay of biomolecules, among other things," Wang says. [Caltech story]

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Professor Wang Advances Photoacoustic Imaging Technology

02-25-20

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed variants of photoacoustic imaging that can show organs moving in real time, develop three-dimensional (3-D) images of internal body parts, and even differentiate cancerous cells from healthy cells. Photoacoustic imaging, a technique for examining living materials through the use of laser light and ultrasonic sound waves, has many potential applications in medicine because of its ability to show everything from organs to blood vessels to tumors. Wang has now further advanced photoacoustic imaging technology with what he calls Photoacoustic Topography Through an Ergodic Relay (PATER), which aims to simplify the equipment required for imaging of this type. [Caltech story]

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Professor Wang Develops World's Fastest Camera

01-21-20

Lihong Wang, Bren Professor of Medical Engineering and Electrical Engineering, has developed the world's fastest camera, a device capable of taking 10 trillion pictures per second. It's so fast that it can even capture light traveling in slow motion. "What we've done is to adapt standard phase-contrast microscopy so that it provides very fast imaging, which allows us to image ultrafast phenomena in transparent materials," says Wang. [Caltech story]

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Microrobots Activated by Laser Pulses Show Promise For Treating Tumors

07-24-19

MedE Professors Wei Gao and Lihong Wang are working on microrobots that can deliver drugs to specific spots inside the body while being monitored and controlled from outside the body. "These micromotors can penetrate the mucus of the digestive tract and stay there for a long time. This improves medicine delivery," Professor Gao says. "But because they're made of magnesium, they're biocompatible and biodegradable." [Caltech story]

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