Biomolecular Engineering to Realize Continuous, Real-time, in vivo Biosensing System

Date: December 2, 2021, 4:00–5:00 PM
Location: Join Zoom Event
Speaker: Professor Koji Sode, Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill and North Carolina State University

Continuous, real-time, in vivo, biosensing of metabolites, and varieties of biomarkers have become important tools to assist/support diagnosis and therapeutic intervention, monitor disease progression, and track patient adherence to therapy. In addition, continuous monitoring enables closed-loop intervention to offer patients innovative and more effective modes of therapy, illustrated in the application of hybrid closed-loop insulin pump systems combined with continuous glucose monitoring systems (CGM). Moreover, intra-cellular real-time continuous monitoring will provide detail, accurate and insight of dynamics of signal transduction, and response toward medical treatment, consequently indispensable information for the physiological or pathological processes.

However, current available sensors for in vivo, real-time, continuous monitoring, which are clinically relevant, are limited in the physiological sensors, or a sole exceptional biosensor for metabolite is the continuous glucose monitoring system.

There have been reported numerous research efforts to realize continuous biosensors, including both implantable and wearable sensors. Most of the efforts have been paid to propose and develop novel transducers and technologies for signal transmission by acknowledging current available sensing molecules and principle to demonstrate continuous biosensors/biosensing. However, scarcely efforts have been paid to realize "future biosensors", by designing, engineering and creating novel biosensing molecules, and also novel biosensing principles acknowledging the superb characteristics of engineered biosensing molecules.

In this presentation, I will introduce the history, current status, and challenge in the development of biomolecular engineering based biosensing technology development, to realize the continuous, real-time, in vivo biosensing system, by addressing new technology development, including our recent challenges, and opening the discussion for future biosensor development.

Professor Koji Sode

Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill and North Carolina State University

Koji Sode Dr. Koji Sode is a Professor of Biomedical Engineering, William R. Kenan Jr. Distinguished Professor in the Joint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill and North Carolina State University. He also serves as the Adjunct Professor at the Institute of Global Innovation Research at Tokyo University of Agriculture and Technology, Japan. He completed his PhD in Engineering at Tokyo Institute of Technology in 1988. Dr. Sode is a Fellow of the National Academy of Inventors and the American Institute for Medical and Biological Engineering (AIMBE). Sode's work has been recognized by 2018 Diabetes Technology Society Leadership Award, among other awards. He holds more than 40 issued US patents (and over 100 foreign patents) that are licensed, co-assigned, or assigned to companies which include suppliers of blood glucose monitoring products in the world. He has published over 330 peer-reviewed articles, and serves as Editor for Biosensors and Bioelectronics and as Congress Committee of The World Congress of Biosensors. His current research interests are 1) Biomolecular engineering toward the application for biodevice development and novel bioprocess design, 2) Biodevice development including biosensors, 3) Synthetic biology to creating novel biocatalyst/microorganisms to realize novel biosensing and bioprocesses.

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