Engineering Tools to Probe and Manipulate the Immune System at Single-cell Resolution

Date: August 30, 2021, 11:00 AM
Location: Online
Speaker: Tatyana Dobreva

Tatyana Dobreva My research focuses on developing experimental and computational tools to probe and manipulate cellular transcriptomes in the context of human health and disease. For probing cellular transcriptome states, I have leveraged single-cell RNA sequencing (scRNA-seq) to understand human immune variability, characterize cell-type specific biases of multiple viral variants within an animal, and assess temporal immune response in the brain to delivery of genetic cargo via an adeno-associated virus (AAV). In the context of manipulating cells, I have made progress on tools for exporting RNA extracellularly and engineering of a transcription factor for modulating macrophage state.